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Clonidine, an alpha-2 receptor agonist, is another drug that has found use as an analgesic adjuvant. In 2021, researchers described a novel type of pain therapy – a CRISPR-dCas9 epigenome editing method for repressing Nav1.7 gene expression which showed therapeutic potential in three mouse models of chronic pain. Evidence of medical marijuana's effect on reducing pain is generally conclusive. Detailed in a 1999 report by the Institute of Medicine, "the available evidence from animal and human studies indicates that cannabinoids can have a substantial analgesic effect". It is mainly the THC strain of medical marijuana that provide analgesic benefits, as opposed to the CBD strain. The study followed participants for 3 years and asked them about the effects of the drug on their condition during this time. The results indicated that indica strains are more likely to improve energy and appetite, while both sativa and indica strains can alleviate nausea to a similar degree. ...

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